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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK4
All Species:
21.82
Human Site:
T390
Identified Species:
36.92
UniProt:
Q9NR20
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR20
NP_003836.1
520
59608
T390
W
E
P
S
L
R
M
T
P
D
Q
A
L
K
H
Chimpanzee
Pan troglodytes
XP_001158495
520
59654
T390
W
E
P
S
L
R
M
T
P
D
Q
A
L
K
H
Rhesus Macaque
Macaca mulatta
XP_001101112
520
59434
T390
W
E
P
S
L
R
M
T
P
D
Q
A
L
K
H
Dog
Lupus familis
XP_534917
565
65190
S434
R
C
L
V
W
E
P
S
L
R
M
T
P
D
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8BI55
632
72542
S501
R
C
L
V
W
E
P
S
L
R
M
T
P
E
Q
Rat
Rattus norvegicus
Q4V8A3
586
65492
G446
K
Y
F
I
N
S
K
G
L
P
R
Y
C
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509988
466
52101
A337
E
N
E
L
E
Q
L
A
C
I
M
E
V
L
G
Chicken
Gallus gallus
Q5ZIU3
526
59419
L395
R
Y
C
T
I
T
T
L
S
D
G
S
I
I
L
Frog
Xenopus laevis
Q2TAE3
750
84138
R528
S
D
P
T
H
Q
H
R
H
S
G
G
H
F
T
Zebra Danio
Brachydanio rerio
XP_693389
634
72240
T498
W
D
P
T
K
R
M
T
P
D
E
A
M
Q
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3D5
722
79590
T484
W
D
P
A
E
R
M
T
P
D
E
A
A
H
H
Honey Bee
Apis mellifera
XP_396369
614
68978
T466
W
D
P
K
K
R
M
T
P
D
E
A
M
R
H
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51568
400
46206
Y271
I
L
G
L
G
W
S
Y
Q
C
D
L
W
S
I
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
R655
P
D
I
I
R
N
Y
R
Y
P
K
S
I
Q
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.8
89.2
76.9
N.A.
65.3
38.7
N.A.
54.2
43.1
28
48.9
N.A.
37.5
42.3
N.A.
N.A.
Protein Similarity:
100
99
91.5
81.2
N.A.
71.5
53.9
N.A.
66.1
59.7
43.3
61.8
N.A.
50.1
59.1
N.A.
N.A.
P-Site Identity:
100
100
100
0
N.A.
0
0
N.A.
0
6.6
6.6
60
N.A.
60
60
N.A.
N.A.
P-Site Similarity:
100
100
100
6.6
N.A.
13.3
6.6
N.A.
20
33.3
26.6
93.3
N.A.
80
86.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.8
22.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.5
36.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
8
0
0
0
43
8
0
0
% A
% Cys:
0
15
8
0
0
0
0
0
8
8
0
0
8
0
0
% C
% Asp:
0
36
0
0
0
0
0
0
0
50
8
0
0
8
0
% D
% Glu:
8
22
8
0
15
15
0
0
0
0
22
8
0
8
0
% E
% Phe:
0
0
8
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
0
8
0
8
0
0
8
0
0
15
8
0
0
8
% G
% His:
0
0
0
0
8
0
8
0
8
0
0
0
8
8
43
% H
% Ile:
8
0
8
15
8
0
0
0
0
8
0
0
15
8
8
% I
% Lys:
8
0
0
8
15
0
8
0
0
0
8
0
0
22
0
% K
% Leu:
0
8
15
15
22
0
8
8
22
0
0
8
22
8
8
% L
% Met:
0
0
0
0
0
0
43
0
0
0
22
0
15
0
0
% M
% Asn:
0
8
0
0
8
8
0
0
0
0
0
0
0
0
8
% N
% Pro:
8
0
50
0
0
0
15
0
43
15
0
0
15
0
0
% P
% Gln:
0
0
0
0
0
15
0
0
8
0
22
0
0
15
15
% Q
% Arg:
22
0
0
0
8
43
0
15
0
15
8
0
0
8
0
% R
% Ser:
8
0
0
22
0
8
8
15
8
8
0
15
0
15
0
% S
% Thr:
0
0
0
22
0
8
8
43
0
0
0
15
0
0
8
% T
% Val:
0
0
0
15
0
0
0
0
0
0
0
0
8
0
8
% V
% Trp:
43
0
0
0
15
8
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
15
0
0
0
0
8
8
8
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _